Skip to main content

Table 1 Post-translational modification of Sp1

From: Functional role of post-translational modifications of Sp1 in tumorigenesis

PTM Modified sites Modified enzymes Functions Ref.
Phosphorylation Ser59 CDK2 Increase Sp1 DNA binding activity [21]
  Ser101 ATM Involve in DNA damage and repair [25]
  Ser131 DNA-PK Upregulate expression of the HIV-1 Tat protein. [26]
  Thr266 Ras-MAPK Increase expression of apolipoprotein A-I [27]
  Thr278/739 JNK1 Increase Sp1 protein stability [28]
  Thr453/739 P42/p44 MAPK Enhance VEGF expression [29]
   ERK1/2 Repress PDGFR-α transcription [30]
   ERK1/2 Inhibit RECK expression and promote cell invasion [31]
  Ser641 PI3K/PKCζ Increase luteinizing hormone receptor (LHR) transcription [32]
  Thr668 CKII Decreased Sp1 DNA binding acticity [23]
  Thr668/Ser670/Thr681 PKCζ Increase PDGF transcription [24]
  Thr739 CDK1 Decrease Sp1 binding activity [22]
Sumoylation Lys16 Sumo-1 Enhance Sp1 degradation [33, 34]
Methylation ND ND Recruit Suv39H1 and HDAC1 to induce chromatin remodeling [35]
Acetylation Lys703 P300 Recruit HDAC1 and p300 to the promoter of the 12(S)-lipoxygenase [36]
Glycosylation Leu56/57 ND Sp1 degradation [37]
  Ser612/641/698/702, Thr640 ND Regulate transcriptional activity of Sp1 [38]
  1. ND: non-determine.