Figure 5

Activation of p38MAPK in RVLM sustained central cardiovascular regulation associated with experimental brain stem death. Temporal changes in MSAP, HR or power density of the LF component of SAP signals in rats that received pretreatment by microinjection bilaterally into RVLM of aCSF (vehicle), p38MAPK inhibitor III (p38MAPK inhibitor), SB203580 (p38MAPK inhibitor) or SB202474 (negative control for p38MAPK inhibitors), 30 min before local application (at arrow) of aCSF or Mev (10 nmol) to the bilateral RVLM. Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus aCSF+aCSF group, and ⁺P < 0.05 versus aCSF+Mev group at corresponding time-points in the post hoc Scheffé multiple-range test.