Table 3 Frequencies of genotypes and alleles of single nucleotide polymorphisms in the IL-12B gene in Graves disease patients with or without Graves ophthalmopathy
SNPs | GD/non-GO | GD/GO | P valuea |
|---|---|---|---|
Number (%) | Number (%) | ||
rs2195940 | Â | Â | Â |
 C/C | 247 (91.14) | 185 (92.50) | 0.60 |
 C/T | 24 (8.86) | 15 (7.50) |  |
 T/T | 0 (0.00) | 0 (0.00) |  |
 C | 518 (95.57) | 385 (96.25) | 0.61 |
 T | 24 (4.43) | 15 (3.75) |  |
rs2853696 | Â | Â | Â |
 A/A | 0 (0.00) | 0 (0.00) | -- |
 A/G | 0 (0.00) | 0 (0.00) |  |
 G/G | 271 (100.00) | 200 (100.00) |  |
 A | 0 (0.00) | 0 (0.00) | -- |
 G | 542 (100.00) | 400 (100.00) |  |
rs2421047 | Â | Â | Â |
 A/A | 56 (20.66) | 46 (23.00) | 0.62 |
 A/G | 145 (53.51) | 98 (49.00) |  |
 G/G | 70 (25.83) | 56 (28.00) |  |
 A | 257 (47.42) | 190 (47.50) | 0.98 |
 G | 285 (52.58) | 210 (52.50) |  |
rs2853694 | Â | Â | Â |
 A/A | 126 (46.49) | 92 (46.00) | 0.99 |
 A/C | 121 (44.65) | 90 (45.00) |  |
 C/C | 24 (8.86) | 18 (9.00) |  |
 A | 373 (68.82) | 274 (68.50) | 0.92 |
 C | 169 (31.18) | 126 (31.50) |  |
rs2569254 | Â | Â | Â |
 C/C | 189 (69.74) | 140 (70.00) | 0.85 |
 C/T | 76 (28.04) | 54 (27.00) |  |
 T/T | 6 (2.21) | 6 (3.00) |  |
 C | 454 (83.76) | 334 (83.50) | 0.91 |
 T | 88 (16.24) | 66 (16.50) |  |
rs1003199 | Â | Â | Â |
 C/C | 114 (42.07) | 76 (38.00) | 0.58 |
 C/T | 121 (44.65) | 92 (46.00) |  |
 T/T | 36 (13.28) | 32 (16.00) |  |
 C | 349 (64.39) | 244 (61.00) | 0.29 |
 T | 193 (35.61) | 156 (39.00) |  |
rs7709212 | Â | Â | Â |
 C/C | 61 (22.51) | 56 (28.00) | 0.16 |
 C/T | 154 (56.83) | 96 (48.00) |  |
 T/T | 56 (20.66) | 48 (24.00) |  |
 C | 276 (50.92) | 208 (52.00) | 0.74 |
 T | 266 (49.08) | 192 (48.00) |  |
rs6868898 | Â | Â | Â |
 C/C | 42 (15.50) | 25 (12.50) | 0.56 |
 C/T | 123 (45.39) | 89 (44.50) |  |
 T/T | 106 (39.11) | 86 (43.00) |  |
 C | 276 (50.92) | 208 (52.00) | 0.74 |
 T | 266 (49.18) | 192 (48.00) |  |