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Table 3 Frequencies of genotypes and alleles of single nucleotide polymorphisms in the IL-12B gene in Graves disease patients with or without Graves ophthalmopathy

From: Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population

SNPs GD/non-GO GD/GO P valuea
Number (%) Number (%)
rs2195940    
 C/C 247 (91.14) 185 (92.50) 0.60
 C/T 24 (8.86) 15 (7.50)  
 T/T 0 (0.00) 0 (0.00)  
 C 518 (95.57) 385 (96.25) 0.61
 T 24 (4.43) 15 (3.75)  
rs2853696    
 A/A 0 (0.00) 0 (0.00) --
 A/G 0 (0.00) 0 (0.00)  
 G/G 271 (100.00) 200 (100.00)  
 A 0 (0.00) 0 (0.00) --
 G 542 (100.00) 400 (100.00)  
rs2421047    
 A/A 56 (20.66) 46 (23.00) 0.62
 A/G 145 (53.51) 98 (49.00)  
 G/G 70 (25.83) 56 (28.00)  
 A 257 (47.42) 190 (47.50) 0.98
 G 285 (52.58) 210 (52.50)  
rs2853694    
 A/A 126 (46.49) 92 (46.00) 0.99
 A/C 121 (44.65) 90 (45.00)  
 C/C 24 (8.86) 18 (9.00)  
 A 373 (68.82) 274 (68.50) 0.92
 C 169 (31.18) 126 (31.50)  
rs2569254    
 C/C 189 (69.74) 140 (70.00) 0.85
 C/T 76 (28.04) 54 (27.00)  
 T/T 6 (2.21) 6 (3.00)  
 C 454 (83.76) 334 (83.50) 0.91
 T 88 (16.24) 66 (16.50)  
rs1003199    
 C/C 114 (42.07) 76 (38.00) 0.58
 C/T 121 (44.65) 92 (46.00)  
 T/T 36 (13.28) 32 (16.00)  
 C 349 (64.39) 244 (61.00) 0.29
 T 193 (35.61) 156 (39.00)  
rs7709212    
 C/C 61 (22.51) 56 (28.00) 0.16
 C/T 154 (56.83) 96 (48.00)  
 T/T 56 (20.66) 48 (24.00)  
 C 276 (50.92) 208 (52.00) 0.74
 T 266 (49.08) 192 (48.00)  
rs6868898    
 C/C 42 (15.50) 25 (12.50) 0.56
 C/T 123 (45.39) 89 (44.50)  
 T/T 106 (39.11) 86 (43.00)  
 C 276 (50.92) 208 (52.00) 0.74
 T 266 (49.18) 192 (48.00)  
  1. Abbreviations: GD, Graves disease; GO, Graves ophthalmopathy; CI, confidence interval.
  2. aP values (two-tailed) were calculated using chi-square tests with 3× 2 contingency tables (genotypes; 2 d.f.) or 2× 2 contingency tables (alleles; 1 d.f.).