Skip to main content

Table 4 Allele frequencies of single nucleotide polymorphism in IL-12B among male Graves disease patients with or without Graves ophthalmopathy

From: Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population

SNPs GD/nonGO GD/GO P Valuea Odds ratio (95% CI)b
Number (%) Number (%)
rs2195940     
 C/C 43 (89.58) 49 (96.08) 0.21  
 C/T 5 (10.42) 2 (3.92)   
 T/T 0 (0.00) 0 (0.00)   
 C 91 (94.79) 100 (98.00) 0.22  
 T 5 (5.21) 2 (2.00)   
rs2853696     
 A/A 0 (0.00) 0 (0.00) --  
 A/G 0 (0.00) 0 (0.00)   
 G/G 48 (100.00) 51 (100.00)   
 A 0 (0.00) 0 (0.00) --  
 G 96 (100.00) 102 (100.00)   
rs2421047     
 A/A 9 (18.75) 6 (11.76) 0.18  
 A/G 32 (66.67) 30 (58.82)   
 G/G 7 (14.58) 15 (29.41)   
 A 50 (52.08) 42 (41.18) 0.12  
 G 46 (47.92) 60 (58.82)   
rs2853694     
 A/A 26 (54.17) 21 (41.18) 0.25  
 A/C 20 (41.67) 24 (47.06)   
 C/C 2 (4.16) 6 (11.76)   
 A 72 (75.00) 66 (64.71) 0.11  
 C 24 (25.00) 36 (35.39)   
rs2569254     
 C/C 32 (66.67) 33 (64.71) 0.38  
 C/T 16 (33.33) 16 (31.37)   
 T/T 0 (0.0) 2 (3.92)   
 C 80 (83.33) 82 (80.39) 0.59  
 T 16 (16.67) 20 (19.61)   
rs1003199     
 C/C 23 (47.92) 13 (25.49) 0.01 1
 C/T 23 (47.92) 28 (54.90)   4.11 (0.82-20.66)
 T/T 2 (4.16) 10 (19.61)   8.85 (1.68-46.69)
 C 69 (71.88) 54 (52.94) 6.00×10-3 1
 T 27 (28.12) 48 (47.06)   2.27 (1.26-4.10)
rs7709212     
 C/C 14 (29.17) 12 (23.53) 0.82  
 C/T 27 (56.25) 31 (60.78)   
 T/T 7 (14.58) 8 (15.69)   
 C 55 (57.29) 55 (53.92) 0.63  
 T 41 (42.71) 47 (46.08)   
rs6868898     
 C/C 5 (10.42) 10 (19.61) 0.19  
 C/T 18 (37.50) 23 (45.10)   
 T/T 25 (52.08) 18 (35.29)   
 C 28 (29.17) 43 (42.16) 0.06  
 T 68 (70.83) 59 (57.84)   
  1. Abbreviations: SNP, single nucleotide polymorphism; GD, Graves disease; GO, Graves ophthalmopathy; CI, confidence interval.
  2. aP values (two-tailed) were calculated using chi-square tests with 3× 2 contingency tables (genotypes; 2 d.f.) or 2× 2 contingency tables (alleles; 1 d.f.).
  3. bOdds ratios and 95% CI per genotype and allele were estimated by applying unconditional logistic regression. P values less than 0.05 were considered significant.