Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population

Table 4 Allele frequencies of single nucleotide polymorphism in IL-12B among male Graves disease patients with or without Graves ophthalmopathy

SNPs	GD/nonGO	GD/GO	P Value^a	Odds ratio (95% CI)^b
SNPs	Number (%)	Number (%)	P Value^a	Odds ratio (95% CI)^b
rs2195940
C/C	43 (89.58)	49 (96.08)	0.21
C/T	5 (10.42)	2 (3.92)
T/T	0 (0.00)	0 (0.00)
C	91 (94.79)	100 (98.00)	0.22
T	5 (5.21)	2 (2.00)
rs2853696
A/A	0 (0.00)	0 (0.00)	--
A/G	0 (0.00)	0 (0.00)
G/G	48 (100.00)	51 (100.00)
A	0 (0.00)	0 (0.00)	--
G	96 (100.00)	102 (100.00)
rs2421047
A/A	9 (18.75)	6 (11.76)	0.18
A/G	32 (66.67)	30 (58.82)
G/G	7 (14.58)	15 (29.41)
A	50 (52.08)	42 (41.18)	0.12
G	46 (47.92)	60 (58.82)
rs2853694
A/A	26 (54.17)	21 (41.18)	0.25
A/C	20 (41.67)	24 (47.06)
C/C	2 (4.16)	6 (11.76)
A	72 (75.00)	66 (64.71)	0.11
C	24 (25.00)	36 (35.39)
rs2569254
C/C	32 (66.67)	33 (64.71)	0.38
C/T	16 (33.33)	16 (31.37)
T/T	0 (0.0)	2 (3.92)
C	80 (83.33)	82 (80.39)	0.59
T	16 (16.67)	20 (19.61)
rs1003199
C/C	23 (47.92)	13 (25.49)	0.01	1
C/T	23 (47.92)	28 (54.90)		4.11 (0.82-20.66)
T/T	2 (4.16)	10 (19.61)		8.85 (1.68-46.69)
C	69 (71.88)	54 (52.94)	6.00×10^-3	1
T	27 (28.12)	48 (47.06)		2.27 (1.26-4.10)
rs7709212
C/C	14 (29.17)	12 (23.53)	0.82
C/T	27 (56.25)	31 (60.78)
T/T	7 (14.58)	8 (15.69)
C	55 (57.29)	55 (53.92)	0.63
T	41 (42.71)	47 (46.08)
rs6868898
C/C	5 (10.42)	10 (19.61)	0.19
C/T	18 (37.50)	23 (45.10)
T/T	25 (52.08)	18 (35.29)
C	28 (29.17)	43 (42.16)	0.06
T	68 (70.83)	59 (57.84)

Abbreviations: SNP, single nucleotide polymorphism; GD, Graves disease; GO, Graves ophthalmopathy; CI, confidence interval.
^aP values (two-tailed) were calculated using chi-square tests with 3× 2 contingency tables (genotypes; 2 d.f.) or 2× 2 contingency tables (alleles; 1 d.f.).
^bOdds ratios and 95% CI per genotype and allele were estimated by applying unconditional logistic regression. P values less than 0.05 were considered significant.

ISSN: 1423-0127