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Table 6 Estimated frequencies of the haplotypes inferred from rs1003199, rs7709212 and rs6868898 among male Graves disease patients with or without Graves ophthalmopathy

From: Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population

Haplotype  SNP GD/nonGO  GD/GO P Valuea P Valueb Odds ratioc
rs1003199 rs7709212 rs6868898 Number (%) Number (%)
HA1 C C C 17 (17.71) 22 (21.57) 1.70 × 10-2 0.50 1.27
HA2 C C T 34 (35.42) 22 (21.57)   0.03 0.51
HA3 C T C 8 (8.33) 4 (3.92)   0.19 0.48
HA4 C T T 10 (10.42) 6 (5.88)   0.24 0.55
HA5 T C C 0 (0.00) 5 (4.90)   0.03 10.89
HA6 T C T 4 (4.17) 6 (5.88)   0.58 1.38
HA7 T T C 3 (3.13) 12 (11.76)   0.02 3.69
HA8 T T T 20 (20.83) 25 (24.51)   0.54 1.23
  1. Abbreviations: GD, Graves disease; GO, Graves ophthalmopathy; CI, confidence interval.
  2. aP values (two-tailed) were calculated using chi-square tests with 8×2 contingency tables (haplotypes; 7 d.f.).
  3. bP values (two-tailed) were calculated using chi-square tests with 2×2 contingency tables (haplotypes; 1 d.f.).
  4. cOdds ratio was calculated using Haldane’s modification of Woolf’ equation.