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Table 6 Estimated frequencies of the haplotypes inferred from rs1003199, rs7709212 and rs6868898 among male Graves disease patients with or without Graves ophthalmopathy

From: Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population

Haplotype

 SNP

GD/nonGO

 GD/GO

P Valuea

P Valueb

Odds ratioc

rs1003199

rs7709212

rs6868898

Number (%)

Number (%)

HA1

C

C

C

17 (17.71)

22 (21.57)

1.70 × 10-2

0.50

1.27

HA2

C

C

T

34 (35.42)

22 (21.57)

 

0.03

0.51

HA3

C

T

C

8 (8.33)

4 (3.92)

 

0.19

0.48

HA4

C

T

T

10 (10.42)

6 (5.88)

 

0.24

0.55

HA5

T

C

C

0 (0.00)

5 (4.90)

 

0.03

10.89

HA6

T

C

T

4 (4.17)

6 (5.88)

 

0.58

1.38

HA7

T

T

C

3 (3.13)

12 (11.76)

 

0.02

3.69

HA8

T

T

T

20 (20.83)

25 (24.51)

 

0.54

1.23

  1. Abbreviations: GD, Graves disease; GO, Graves ophthalmopathy; CI, confidence interval.
  2. aP values (two-tailed) were calculated using chi-square tests with 8×2 contingency tables (haplotypes; 7 d.f.).
  3. bP values (two-tailed) were calculated using chi-square tests with 2×2 contingency tables (haplotypes; 1 d.f.).
  4. cOdds ratio was calculated using Haldane’s modification of Woolf’ equation.