Haplotype

SNP

GD/nonGO

GD/GO

P Value^{a}

P Value^{b}

Odds ratio^{c}


rs1003199

rs7709212

rs6868898

Number (%)

Number (%)


HA1

C

C

C

17 (17.71)

22 (21.57)

1.70 × 10^{2}

0.50

1.27

HA2

C

C

T

34 (35.42)

22 (21.57)
 
0.03

0.51

HA3

C

T

C

8 (8.33)

4 (3.92)
 
0.19

0.48

HA4

C

T

T

10 (10.42)

6 (5.88)
 
0.24

0.55

HA5

T

C

C

0 (0.00)

5 (4.90)
 
0.03

10.89

HA6

T

C

T

4 (4.17)

6 (5.88)
 
0.58

1.38

HA7

T

T

C

3 (3.13)

12 (11.76)
 
0.02

3.69

HA8

T

T

T

20 (20.83)

25 (24.51)
 
0.54

1.23

 Abbreviations: GD, Graves disease; GO, Graves ophthalmopathy; CI, confidence interval.
 ^{a}P values (twotailed) were calculated using chisquare tests with 8×2 contingency tables (haplotypes; 7 d.f.).
 ^{b}P values (twotailed) were calculated using chisquare tests with 2×2 contingency tables (haplotypes; 1 d.f.).
 ^{c}Odds ratio was calculated using Haldane’s modification of Woolf’ equation.