Figure 1

Sap6 participates in the breakout process of C. albicans from phagocytosis of THP-1 monocytes. Candida cells and THP-1 cells were co-cultured at 37°C for 1 hr. Then cells were harvested and prepared for microscope inspection. Thirty views of microscope for each sample were subjected to dissect and calculate the growth characters of co-cultured Candida cells. SC5314: the wild type strain; Δsap5: the SAP5 gene deleted mutant; Δsap6: the SAP6 gene deleted mutant; short hypha: filament </= two mother cell length; long hypha: filament > two mother cell length. *: the difference between Δsap6 strain and wild type/Δsap5 strains is considered to be statistically significant (t test, P value < 0.01).