From: Current understanding on micro RNAs and its regulation in response to Mycobacterial infections
Micro-RNAs | Identified regulation mechanism | Reference |
---|---|---|
miR-29 | Suppress the IFN-γ production by targeting IFN-γ mRNA | Ma et al.[48] |
miR-29 and Let-7e | Inhibit the apoptosis by caspases 3 and 7 (major effector caspases) | Sharbati et al.[47] |
miR 125b | Block the TNF-α biosynthesis | Rajaram et al.[49] |
miR-155 | Enhance the TNF-α biosynthesis | Rajaram et al.[49] |
miR-155 | Repress Bach1 and SHIP1 to support the dormancy and survival of M. tuberculosis in host | Kumar et al.[51] |
miR-99b | Negatively regulate the production of proinflammatory cytokine that leads to reduced growth of M. tuberculosis | Singh et al,[50] |