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Table 1 IFN- γ treatment enhances the sensitivity of cancer cells to L6scFv- FasL ext mediated apoptosis

From: A recombinant scFv-FasLext as a targeting cytotoxic agent against human Jurkat-Ras cancer

Target cells % Specific killing of 104cells/well by L6scFv-FasLext(μl/well)
  30 μl 10 μl 3 μl 1 μl 0.3 μl 0.1 μl
HeLa 84 80 64 32 4 3
IFN-γ-HeLa 87 85 62 60 46 24
468 58 53 41 11 −5 −3
IFN-γ-468 83 81 79 69 35 17
DKBK3 21 13 11 13 10 11
IFN-γ-DKBK3 78 66 44 31 17 7
  1. Breast cancer cells were sensitized by IFN-γ in vitro. Under the cytotoxicity assay condition, IFN-γ (100 ng/ml) enhanced 3-10 folds of the target susceptibility to L6scFv-FasLext.