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Figure 3 | Journal of Biomedical Science

Figure 3

From: Rivaroxaban modulates electrical and mechanical characteristics of left atrium

Figure 3

Effects of rivaroxaban (300 nM) with and without NG-nitro-L-arginine methyl ester (L-NAME, 100 μM), or indomethacin (10 μM) and on the left atrial (LA) action potential (AP) and contractility. An example and average data (n = 7) show that rivaroxaban (10, 30, 100, and 300 nM) solutions concentration-dependently shortened the 90% repolarization of the AP duration (APD90) of LA. The resting membrane potential (RMP), AP amplitude (APA), and contractile forces of LA did not significantly change with L-NAME, indomethacin and additional rivaroxaban treatment. * P < 0.05 vs. control.

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