Figure 2

The number of changes in heavy atoms between the original and the substituted amino acid. For instance, in change 0–1 (no or one change in the number of heavy atoms by substitution), the cases of ULS are more frequent than those of LLS. An I-form line on each bar denotes a standard deviation obtained by the bootstrap method with 1,000 resampling. The distributions do not overlap in the number of changes 0–1 and 2–3.