CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein

Table 5 Variants classified as ULS showing polymorphism or normal IHC and MSS

No	Variant	Definition of ULS^a	Polymorphism	MLH1	MSH2	MSH6	MSI	References
20	K13T	3	<0.01	Normal	Normal	Normal	S	[[49]]
21	A25V	1	≥0.01	ND	ND	ND	ND	db S NP, 1000 Genomes
22	G39E	1	≥0.01	ND	ND	ND	ND	db S NP, 1000 Genomes
23	G54A	3	NA	Normal	Normal	Normal	S	[[51]]
24	S65L	3	<0.01	Normal	Normal	Normal	S	[[49]]
25	C196F	1	≥0.01	ND	ND	ND	ND	db S NP, 1000 Genomes
26	R468H	3	<0.01	Normal	Normal	Normal	S	[[49]]
27	S503C	3	<0.01	Normal	Normal	Normal	S	[[49]]
28	R635G	3	NA	Normal	Normal	Normal	S	[[52]]
29	l886V	1	≥0.01	ND	ND	ND	ND	1000 Genomes
30	l1054F	3	NA	Normal	Normal	Normal	S	[[34]]
31	E1163V	1	≥0.01	ND	ND	ND	ND	1000 Genomes
32	E1196K	1	≥0.01	ND	ND	ND	ND	db S NP 1000 Genomes
33	E1234Q	1	≥0.01	ND	ND	ND	ND	db S NP 1000 Genomes
34	E1304K	1	≥0.01	ND	ND	ND	ND	1000 Genomes

ISSN: 1423-0127