CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein

Terui, Hiroko; Akagi, Kiwamu; Kawame, Hiroshi; Yura, Kei

doi:10.1186/1423-0127-20-25

Journal of Biomedical Science

Table 8 Classification results of UVs in MSH6 by CoDP

From: CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein

The variants with no impact on MSH6						The variants with moderate impact on MSH6		The variants with impact on MSH6
Variants	Score	Variants	Score	Variants	Score	Variants	Score	Variants	Score	Variants	Score
S9G	0.000	S360I	0.000	L815I	0.180	G670V	0.595	L370S	0.832	A1021D	0.988
A20V	0.000	R361H	0.000	P831A	0.060	S1049F	0.572	Y397C	0.976	R1024W	0.938
A20D	0.000	T369I	0.009	D857N	0.426	I1227L	0.619	L435P	0.942	D1026Y	0.995
N21S	0.000	E381K	0.001	V867G	0.189			A457P	0.951	D1031V	0.722
A25S	0.000	D390N	0.003	V878A	0.009			R468C	0.992	R1034Q	0.724
A36V	0.000	Y397F	0.003	D880E	0.000			V474A	0.930	A1055T	0.935
P42S	0.000	I425V	0.115	Q889H	0.022			V480L	0.853	D1058S	0.975
W50R	0.000	I442T	0.017	I891M	0.031			E484K	0.826	V1059A	0.716
A81T	0.000	E446N	0.027	L893V	0.016			V509A	0.969	A1064V	0.846
A81V	0.000	N455T	0.000	R901H	0.035			I516N	0.740	Y1066C	0.999
K99N	0.003	Q475H	0.261	D904E	0.006			T521I	0.911	P1087H	0.978
I120V	0.000	K476E	0.145	V907A	0.001			Y535C	0.894	P1087R	0.995
E122K	0.000	M492V	0.530	E983Q	0.074			Y538S	0.998	R1095H	0.692
K125E	0.000	R497T	0.028	N984H	0.006			D575Y	0.997	R1095C	0.996
L147H	0.000	K498R	0.000	F985L	0.016			S580L	0.997	T1100R	0.860
A159V	0.000	Q522R	0.097	R988L	0.017			P656L	0.943	I1115T	0.802
H164P	0.000	P531T	0.003	P991L	0.065			S682C	0.653	T1142M	0.864
K185E	0.000	E533D	0.006	T1008I	0.302			S682F	0.998	G1148R	1.000
K187T	0.000	E546G	0.031	R1024Q	0.053			G685A	0.939	G1157S	0.964
E192V	0.000	E546Q	0.003	Q1048E	0.002			L700F	0.985	A1162P	0.970
V195F	0.015	S549F	0.468	V1056M	0.360			S702G	0.951	T1175S	0.822
D197H	0.001	Y556F	0.162	R1068G	0.312			F706S	0.996	E1187G	0.998
E198A	0.000	I570V	0.054	P1073S	0.001			R761G	0.922	L1201F	0.984
P202A	0.000	R577H	0.522	P1073R	0.042			C765W	1.000	D1213V	0.932
M208V	0.000	F582L	0.146	V1078A	0.004			G770V	0.994	E1214A	0.992
V210A	0.000	I608V	0.033	P1082S	0.018			R772Q	0.954	R1217K	0.880
V215I	0.000	K610N	0.009	P1082L	0.012			W777R	0.994	T1219I	0.944
D217Y	0.001	E619D	0.291	P1087T	0.056			A780G	0.713	T1225M	0.888
E220D	0.000	P623A	0.010	P1087S	0.201			I795T	0.707	R1242L	0.966
E221D	0.000	G624S	0.072	E1090K	0.007			L798V	0.919	T1243S	0.650
N223D	0.000	E639K	0.005	T1100M	0.025			Y850C	1.000	V1253E	0.856
N223S	0.000	R644S	0.057	K1101N	0.002			K854M	0.826	R1263C	0.767
S227I	0.000	K646R	0.223	P1110S	0.376			S860F	0.982	R1263H	0.669
E229G	0.008	I651T	0.000	I1113T	0.045			K866T	0.685	M1267T	0.946
P233R	0.000	M654I	0.001	E1121D	0.000			Q889P	0.682	C1275Y	0.992
R243C	0.005	S666P	0.008	A1151V	0.055			L909S	0.967	T1284M	0.913
R243H	0.000	D667H	0.453	V1160I	0.117			D943Y	0.900	A1303T	0.981
I245L	0.000	I669T	0.000	D1181E	0.540			Y977H	0.945	A1303G	0.916
I251V	0.000	P673A	0.405	M1202V	0.009			R988C	0.716	R1321G	0.825
I258T	0.000	E675D	0.000	V1232L	0.318			Y994H	0.895	L1353W	0.989
F265C	0.119	K676R	0.006	H1248D	0.022			S998T	0.853
T269S	0.000	Q698K	0.005	V1253L	0.068
K270M	0.001	Q698E	0.006	V1260I	0.001
E277D	0.000	A704G	0.008	N1273S	0.008
S285I	0.000	T719I	0.006	E1274K	0.006
G289D	0.000	T720A	0.033	S1279P	0.014
G289E	0.000	T720I	0.024	I1283V	0.001
K295E	0.000	I725M	0.000	E1310D	0.001
K295R	0.001	I725V	0.000	E1311D	0.004
R300P	0.001	F726S	0.208	R1321S	0.128
S314I	0.000	R761K	0.015	M1326I	0.001
S314R	0.001	T764N	0.005	M1326T	0.002
S315F	0.003	P768A	0.201	S1329L	0.014
T319M	0.000	C783S	0.409	R1331L	0.011
P320T	0.000	A787V	0.063	R1334Q	0.000
A326V	0.000	V800L	0.000	D1346N	0.001
T327S	0.000	V800A	0.000	L1354Q	0.018
F340S	0.001	D803G	0.003	K1358E	0.001
S360G	0.000	S806F	0.450

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ISSN: 1423-0127

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