Figure 4
From: Beyond NF-κB activation: nuclear functions of IκB kinase α
Regulations of cell cycle progression by nuclear IKKα. In the nucleus, IKKα is involved in cell cycle arrest at G1/S transition by increasing Smad transcriptional activity, facilitating cyclin D1 proteasomal degradation, and FGF gene expression. Nuclear IKKα also promotes G2/M phase progression by increasing kinase activity of Aurora A and by de-repressing 14-3-3 σ gene expression through preventing DNA and histone methylation on the promoter.