Figure 5
From: Beyond NF-κB activation: nuclear functions of IκB kinase α
Nuclear IKKα and tumor progression. Nuclear IKKα promotes tumor growth by enhancing NF-κB- and Notch-dependent gene transcriptions and suppressing FOXA2-mediated gene expression. By promoting Smad and STAT3 transcriptional activity and suppressing maspin gene expression, nuclear IKKα contributes to cancer metastasis.