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Figure 2 | Journal of Biomedical Science

Figure 2

From: Distinct regulation of dengue virus-induced inflammasome activation in humanmacrophage subsets

Figure 2

Activation of NLRP3 inflammasome in DV–infected M-Mϕ.M-Mϕ is incubated with DV directly (A), or after LPS priming(B). DV activates Syk via CLEC5A to up-regulate thetranscription of IL-1β (slightly) and IL-18 (significantly), but isunable to induce NLRP3 transcription. LPS priming further up-regulatesthe transcription of IL-1β, but down-regulates IL-18 transcription.LPS priming cannot enhance the transcription of NLRP3. NLRP3inflammasome is not activated in DV-infected M-Mϕ, and thus, isunable to activate caspase-1 to process pro- IL-1β and pro-IL-18.NLRP, NLR family PYD-containing protein; DV, dengue virus; LPS,lipopolysaccharides; IL-1β, interleukin -1beta.

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