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Figure 7 | Journal of Biomedical Science

Figure 7

From: Distinct regulation of dengue virus-induced inflammasome activation in humanmacrophage subsets

Figure 7

The combination of NLRP3 inflammasome-processed cytokines and IL-23during DV infection induced the production of IL-17 fromTh17/γδ Tcells. Stimulation of TLRs in GM-Mϕ withDV can induce the activation of NF-κB and MAPK, which promotes thetranscription of a range of pro-inflammatory cytokines. NLRP3inflammasome-activated caspase-1 further processes the pro-IL-1βand pro-IL-18 into their mature cytokine form, IL-1β and IL-18.IL-1β can also enhance the production of IL-23 and IL-6. Thereleased IL-1β, IL-18, and IL-23 induce Th17/γδ T cellsto produce pro-inflammatory cytokines which are responsible for hostimmune responses against DV infection.

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