Figure 2
From: Involvement of STIM1 and Orai1 in EGF-mediated cell growth in retinal pigment epithelial cells
Calcium chelators reduced the EGF-mediated cell proliferation and migration in the ARPE-19 cells. (A) Pre-treatment of EGTA (1 mM) or BAPTA-AM (2.5 μM) inhibited EGF-stimulated cell proliferation (*** p < 0.001 and ** p < 0.01, respectively) by WST-1 assay. (B) EGTA (1 mM) and BAPTA-AM (5 μM) suppressed EGF-mediated ARPE-19 cell migration. (C) The quantitative analysis of Figure 2B showed the statistical significance of suppression in EGF-mediated cell migration by EGTA and BAPTA-AM.