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Table 3 Univariate and multivariate analyses for the overall survival

From: Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance

 

Univariate analysis

Multivariate analysis

HR (95% CI)

P-value

HR (95% CI)

P-value

Age#

≤30

NA§

 

NA§

 
 

31-40

1 (reference)

 

1 (reference)

 
 

41-50

0.88 (0.43–1.81)

0.721

0.64 (0.25–1.62)

0.343

 

51-60

0.67 (0.31–1.47)

0.318

0.83 (0.32–2.15)

0.705

 

61-70

1.17 (0.52–2.66)

0.704

0.96 (0.30–3.08)

0.949

 

≥71

0.51 (0.11–2.29)

0.376

0.52 (0.06–4.73)

0.564

Alcohol#

No

1 (reference)

 

1 (reference)

 
 

Yes

1.03 (0.62–1.74)

0.899

1.07 (0.54–2.11)

0.842

Smoking#

No

1 (reference)

 

1 (reference)

 
 

Yes

1.44 (0.71–2.93)

0.315

1.98 (0.79–4.97)

0.145

Betel nut#

No

1 (reference)

 

1 (reference)

 
 

Yes

1.64 (0.83–3.26)

0.156

1.00 (0.42–2.37)

0.999

TNM staging#

1

1 (reference)

 

1 (reference)

 
 

2

1.18 (0.50–2.78)

0.703

0.76 (0.26–2.23)

0.618

 

3

2.35 (0.95–5.86)

0.066

2.16 (0.78–6.02)

0.140

 

4

4.21 (2.12–8.40)

<0.001

3.53 (1.41–8.81)

0.007

EGFR

Negative

1 (reference)

   
 

Positive

1.19 (0.70–2.02)

0.516

NA

 

EGFR GCN

Non-amplified

1 (reference)

   
 

Amplified

0.94 (0.57–1.57)

0.822

NA

 

EGFRvIII#

Low

1 (reference)

   
 

High

2.27 (1.36–3.79)

0.002

1.98 (1.01–3.87)

0.046

PTEN

Negative

1 (reference)

   
 

Positive

1.26 (0.77–2.08)

0.359

NA

 

pAKT#

Negative

1 (reference)

   
 

Positive

2.51 (1.00–6.27)

0.050

2.67 (1.01–7.07)

0.049

  1. CI confidence interval, HR hazard ratio, NA not assessed.
  2. #Factors included in multivariate analysis.
  3. §Not assessed because the patient number was too small.
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Journal of Biomedical Science

ISSN: 1423-0127