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Table 2 Association of pemetrexed treatment responses with clinicopathological data from lung adenocarcinoma patients

From: Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC

  No. of patients Efficacy χ2 P value
CR + PR
Age (years)
 < 60 50 16 3.7 0.06
 ≥ 60 56 9
Gender
 Male 62 10 4.6 0.03
 Female 44 15
Disease stage
 IIIB 78 24 5.6 0.02
 IV 28 1
ECOG grade
 0 36 13 5.0 0.08
 1 54 10
 2 16 2
Genotype
 −6 bp/-6 bp 59 19 5.5 0.02
 −6 bp/+6 bp 47 6
Expression of TS protein
 TS(+) 67 11 5.1 0.02
 TS(−) 39 14