Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC

Table 2 Association of pemetrexed treatment responses with clinicopathological data from lung adenocarcinoma patients

	No. of patients	Efficacy	χ²	P value
	No. of patients	CR + PR	χ²	P value
Age (years)
< 60	50	16	3.7	0.06
≥ 60	56	9	3.7	0.06
Gender
Male	62	10	4.6	0.03
Female	44	15	4.6	0.03
Disease stage
IIIB	78	24	5.6	0.02
IV	28	1	5.6	0.02
ECOG grade
0	36	13	5.0	0.08
1	54	10
2	16	2
Genotype
−6 bp/-6 bp	59	19	5.5	0.02
−6 bp/+6 bp	47	6	5.5	0.02
Expression of TS protein
TS(+)	67	11	5.1	0.02
TS(−)	39	14	5.1	0.02

ISSN: 1423-0127