Skip to main content

Table 4 Association between the adverse drug reactions and TS gene 3'-UTR 1494 bp

From: Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC

  Grade Genotype (n = cases) χ2 P
−/− (n = 59) −/+ (n = 47)
Leukopenia I, II 22 16 0.057 0.483
III, IV 0 1 1.241 0.449
Neutropenia I, II 21 19 0.117 0.437
III, IV 0 0 - -
Thrombocytopenia I, II 10 11 0.457 0.330
III, IV 0 0 - -
Nausea, Vomiting I, II 9 10 0.447 0.337
III, IV 0 1 1.241 0.449
Diarrhea I, II 11 9 0.003 0.573
III, IV 0 0 - -
Constipation I, II 14 10 0.057 0.498
III, IV 0 0 - -
Fatigue I, II 15 10 0.155 0.435
III, IV 0 0 - -
Renal damage I, II 0 0 - -
III, IV 0 0 - -
Liver damage I, II 2 1 0.143 0.590
  III, IV