Skip to main content

Table 4 Association between the adverse drug reactions and TS gene 3'-UTR 1494 bp

From: Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC

 

Grade

Genotype (n = cases)

χ2

P

−/− (n = 59)

−/+ (n = 47)

Leukopenia

I, II

22

16

0.057

0.483

III, IV

0

1

1.241

0.449

Neutropenia

I, II

21

19

0.117

0.437

III, IV

0

0

-

-

Thrombocytopenia

I, II

10

11

0.457

0.330

III, IV

0

0

-

-

Nausea, Vomiting

I, II

9

10

0.447

0.337

III, IV

0

1

1.241

0.449

Diarrhea

I, II

11

9

0.003

0.573

III, IV

0

0

-

-

Constipation

I, II

14

10

0.057

0.498

III, IV

0

0

-

-

Fatigue

I, II

15

10

0.155

0.435

III, IV

0

0

-

-

Renal damage

I, II

0

0

-

-

III, IV

0

0

-

-

Liver damage

I, II

2

1

0.143

0.590

 

III, IV

    
Back to article page