Table 3 Clinicopathological features of the 389 patients with primary breast carcinomas according to methylation status of NDRG1

Menopausal status

Pre-

162

51

1.0

Post-

227

70

1.86(0.84-4.14)

0.126

Tumor size

<1.0

7

3

1.0

1.0-1.9

136

45

0.84(0.14-4.88)

0.842

2-3

200

61

0.64(0.11-3.69)

0.615

≥3.1

46

12

0.55(0.08-3.59)

0.535

Histological grade

Well

150

35

1.0

Moderate

207

72

1.89(1.20-3.20)

0.017

Poor

32

14

2.96(1.19-7.39)

0.020

Metastasis

Negative

232

63

1.0

Positive

157

58

1.94(1.10-3.40)

0.021

Lymph node invasion

Negative

86

20

1.0

Positive

303

101

2.22(1.19-4.11)

0.011

TNM stage

0/I

87

20

1.0

II

173

53

1.88(0.96-3.67)

0.064

III/IV

129

48

2.82(1.41-5.62)

0.003

p53 mutation

Wild

160

50

1.0

Mutant

229

71

1.04(0.64-1.70)

0.865

HER2 status

Negative

270

86

1.0

Positive

119

35

0.83(0.49-1.39)

0.472

Ki67 proliferation index

<10%

93

32

1.0

10%-32%

152

44

0.66(0.35-1.25)

0.200

≧33%

144

45

0.78(0.41-1.48)

0.441