Representative light micrographs of rat kidney. (A) Renal cortex of a control rat-shows normal architecture [H& E X 200]. (B) Renal medulla of a control rat shows normal architecture [H & E, X 200]. (C) Renal cortex of a TDF treated rat. The proximal convoluted tubules were distorted and their lining epithelium was destroyed (white arrow, H & E, X 200). Some glomeruli were shrunken (black arrow). (D) Renal medulla of a TDF treated rat–There was mild destruction of the lining epithelium of the loops of Henle and the convoluted tubules (black arrow) H & E, X 200.