Representative electron micrographs of control kidney and TDF treated kidney. Control kidneys A & B. (A) Normal Kidney tubules (original magnification × 22000). (B) Normal mitochondrial structure (black arrow) in the renal tubules of control rats (original magnification × 22000) .C- F. Representative electron micrographs of TDF treated rat kidney. (C) Vacuoles seen in the cytoplasm of the kidney tubule (black arrow) Less number of lysosomes (white arrow) (D) Swollen mitochondria (M) black arrow(original magnification × 22 000) (E). Disruption of mitochondrial cristae (black arrow) in the renal tubules of TDF treated rats (F) Amorphous deposits in the mitochondrial matrix (white arrow)x 22,000.