From: Priming adult stem cells by hypoxic pretreatments for applications in regenerative medicine
Cell type | pO2modulation | Cell differentiation/ mechanism | Ref. |
---|---|---|---|
BM-MSCs | CoCl2 | Dopaminergic neuron-like cells/HIF-1α dependent activation of EPO, VEGF, p21 | [115] |
Rat MSCs | Continuous hypoxia | Increased chondrogenesis/activation of HIF-1α, Akt, p38 MAPK, SOX-9 | [119] |
Human MSCs | Continuous hypoxia | Inhibited osteogenesis/ HIF-1α dependent inhibition of RUNX2 | [121] |
MSCs | Continuous hypoxia | Inhibited hypertrophic chondrogenesis | [122] |
BM-MSCs | Continuous hypoxia in alginate beads | Increased chondrogenesis/ HIF-1α dependent stimulation of SOX-9 | [123] |
Human BM-MSCs | Continuous hypoxia in gelatine hydrogel | Increased chondrogenesis | [124] |
Human ADSCc | Continuous hypoxia and chondrogenic medium | Increased chondrogenesis | [126] |
ADSCc | Continuous 2% oxygen tension | Decreased chondrogenesis and osteogenesis | [127] |