The effects of TAM and/or tranilast on viability in MCF-7 (A) and MDA-MB-231 (B) cells. Cells were treated with TAM, tranilast and combination both for 48 h. Control wells were treated with equivalent amount of media alone. Treatment with TAM and tranilast combined significantly decreased the viability compared with TAM or tranilast alone. The results showed the mean and SE from triplicated experiments. (*p < 0.05; **p < 0.01 ***p< 0.001 compared with control).