Figure 8
From: Tranilast enhances the anti-tumor effects of tamoxifen on human breast cancer cells in vitro
Tranilast and TAM regulate the extracellular TGF-β1 protein secreted from cultured human breast cancer cells. MCF-7 and MDA-MB-231 cells were cultured without drugs (control) or in the presence of 2 μM TAM, 200 μM tranilast or a combination two for 48 h. Results represent at least two independent experiments ± SEM. (A) TGF-β1 protein levels in medium from MCF-7 cells; (B) TGF-β1 protein levels in medium from MDA-MB-231 cells (*p < 0.05, **p < 0.01, ***p < 0.001).