Figure 4

The summary of the effects of naloxone, naloxonazine, naltrindole and nor-binaltorphimine on the EA-induced exacerbation of sleep disruptions. Panels A, B and C demonstrate the percentage of NREM sleep acquired from the indicated time blocks. Panels D. E and F depict the percentage of REM sleep obtained from the indicated time blocks. The bars from the left to the right in each panel represent the data acquired from the PFS + EA + pilocarpine group, the naloxone + EA + pilocarpine group, the naloxonazine + EA + pilocarpine group, the naltrindole + EA + pilocarpine and the nor-binaltorphimine + EA + pilocarpine group. Panels A, B and C represent the percentage of time spent in NREM sleep during the 12-h dark period, the time block between 5-12 h of the dark period, and the 12-h light period, respectively. Panels D, E and F indicate the percentage of time spent in REM sleep during the 12-h dark period, the time block between 5-12 h of the dark period, and the 12-h light period, respectively. **: p < 0.01 vs. the values acquired from the PFS + EA + pilocarpine group.