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Table 1 DNA transposon vectors and their main characteristics
From: DNA transposon-based gene vehicles - scenes from an evolutionary drive
| Transposon | Transposon family | Target sequence | Integration preference | Cargo capacity | Footprint | Overproduction inhibition | Hyperactive transposase | References |
|---|---|---|---|---|---|---|---|---|
| Sleeping Beauty | Tc1/mariner | TA | Fairly random (31-39% into genes) | ~ 10 kb | C(A/T)GTA | Yes | SB100X | [50–54] |
| Frog Prince | Tc1/mariner | TA | ND | ND | C(A/T)GTA | ND | None | [30] |
| Hsmar1 | Tc1/mariner | TA | Fairly random (44% into genes) | ND | T(T/A)A | Yes | None | [34, 55, 56] |
| Himar1 | Tc1/mariner | TA | Fairly random | 4 kb | ACTA | Yes | C9 | [31, 57–59] |
| Passport | Tc1/mariner | TA | Transcriptional units (63% into genes) | ND | ND | Yes | None | [33] |
| Tol2 | hAT | 8 bp random sequence | Transcriptional units (39-48% into genes) | > 11 kb | 8 bp random sequence | Limited | None | [60–62] |
| TcBuster | hAT | 8 bp random sequence | Transcriptional units | ND | 8 bp random sequence | ND | TcBusterCOV596A | [36, 37] |
| PiggyBac | PiggyBac | TTAA | Transcriptional units (47-67% into genes) | 100 kb | None | Conflicting reports | 7pB, hyPBase | [27–29, 63, 64] |
| PiggyBat | PiggyBac | TTAA | Transcriptional units | ND | ND | ND | None | [35] |
