Table 3 KEGG analysis of predicted target genes of miRNAs in rat hippocampus

Glutamatergic Synapse

Gnai3, Gng10, Pla2g4a, Plcb4, Slc17a6, Chp2

miR-135a, miR-144, miR-22, miR-350, miR-770

Gabaergic Synapse

Gnai3, Gng10, Plcl1, Slc38a5

miR-144, miR-22, miR-34c, miR-674-3p, miR-873, miR-878

Cholinergic Synapse

Chrm3, Gnai3, Gng10, Plcb4, Bcl2

miR-22, miR-144, miR-770, miR-34b, miR-34c, miR-878

Dopaminergic Synapse

Gnai3, Gng10, Kif5a, Arrb2, Plcb4, Ppp2cb

miR-22, miR-144, miR-347, miR-181c, miR-30a*, miR-770, miR-26b, miR-133b, miR-878

Serotonergic Synapse

Gnai3, Gng10, Pla2g4a, Plcb4, Ptgs1, Raf1

miR-22, miR-144, miR-770, miR-181c, miR-382, miR-873, miR-770

Long-Term Potentiation

Plcb4, Raf1, Chp2

miR-770, miR-135a, miR-350

Long-Term Depression

Gnai3, Pla2g4a, Plcb4, Ppp2cb, Raf1

miR-22, miR-144, miR-770, miR-26b, miR-133b, miR-878

Retrograde Endocannabinoid Signaling

Gnai3, Gng10, Plcb4, Slc17a6

miR-22, miR-144, miR-770, miR-350

Synaptic Vesicle Cycle

Cplx1, Clta, Cltc, Ap2a2, Atp6v1e1, Slc17a6, Vamp2, Atp6v0d1

miR-129, miR-135a, miR-133b, miR-350, miR-152, miR-34c, miR-194, miR-431, miR-382, miR-872

Neurotrophin Signaling Pathway

Prkcd, Raf1, Bcl2, Tp53

miR-181c, miR-26b, miR-350, miR-34c, miR-874, miR-34b, miR-770

Alzheimer’s Disease

Atp5g3, Plcb4, Sdhd, Chp2, Adam17, Uqcrc2

miR-34b, miR-878, miR-770, miR-674-3p, miR-135a, miR-350, miR-194, miR-26b

Cocaine Addiction

Gnai3

miR-22

Amphetamine Addiction

Chp2

miR-135a, miR-350

MAPK Signaling Pathway

Gadd45a, Arrb2, Pak1, Pla2g4a, Raf1, Chp2, Stk3, Tp53, Map3k12, Cacna2d1

miR-134, miR-152, miR-431, miR-181c, miR-30a*, miR-144, miR-770, miR-135a, miR-350, miR-665, miR-34b, miR-34c, miR-874, miR-191

Calcium Signaling Pathway

Chrm3, Adrb3, Slc25a5, Pde1c, Phkg2, Plcb4, Plcd1, Ptafr, Chp2, Cckbr

miR-878, miR-26b, miR-347, miR-134, miR-135a, miR-350, miR-674-3p, miR-770, miR-191, miR-152, miR-30a*

PI3K-Akt signaling pathway

Cdk2, Col2a1, Col4a4, Csf1r, Gng10, Hgf, Pck1, Ppp2cb, Ptk2, Raf1, Bcl2, Tlr2, Tp53, Ywhag

miR-134, miR-152, miR-26b, miR-133b, miR-878, miR-34b, miR-34c, miR-872, miR-144, miR-135a, miR-770, miR-181c