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Table 5 MiRNAs as targets for cancer therapy

From: MicroRNA: a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy

Cancer type

miRNA target and its role in cancer

Delivery system to modulate the miRNA in vivo*

Reference

Breast cancer

miR-34a – Tumor suppressor

Cationic liposomes

[109]

Glioblastoma

miR-145 – Tumor suppressor

Adenoviruses

[110]

Glioblastoma

miR-221-222 – Oncogene

Adenoviruses

[111]

Glioblastoma Multiforme (GBM)

miR-9 – promote expression of P-gp (a multidrug resistance efflux transporter)

- Mesenchymal stem cell-derived exosomes

[112]

- To deliver anti-miR-9 to temozolomide-resistant GBM to reduce P-gp expression for resistance reversal

Hepatocellular carcinoma

miR-26 – Tumor suppressor

Adenoviruses

[113]

Lung cancer

let-7 – Tumor suppressor

Adenoviruses

[114]

Lung cancer

miR-34a – Tumor suppressor

Cationic liposomes

[115]

Lymphoma

miR-155 – Oncogene

Polymer-based nanoparticles

[116]

Medulloblastoma

miR-17 ~ 92 cluster family – Sonic Hedgehog signaling

8-mer seed-targeting locked nucleic acid (LNA)-modified anti-miR oligonucleotides (nude mice)

[117]

Pancreatic cancer

miR-21 – Oncogene

Lentiviruses

[118]

  1. * The miRNA target can be modulated by anti-miRNA oligonucleotides or miRNA-expressing constructs (delivered by viral or non-viral vectors).