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Table 5 MiRNAs as targets for cancer therapy

From: MicroRNA: a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy

Cancer type miRNA target and its role in cancer Delivery system to modulate the miRNA in vivo* Reference
Breast cancer miR-34a – Tumor suppressor Cationic liposomes [109]
Glioblastoma miR-145 – Tumor suppressor Adenoviruses [110]
Glioblastoma miR-221-222 – Oncogene Adenoviruses [111]
Glioblastoma Multiforme (GBM) miR-9 – promote expression of P-gp (a multidrug resistance efflux transporter) - Mesenchymal stem cell-derived exosomes [112]
- To deliver anti-miR-9 to temozolomide-resistant GBM to reduce P-gp expression for resistance reversal
Hepatocellular carcinoma miR-26 – Tumor suppressor Adenoviruses [113]
Lung cancer let-7 – Tumor suppressor Adenoviruses [114]
Lung cancer miR-34a – Tumor suppressor Cationic liposomes [115]
Lymphoma miR-155 – Oncogene Polymer-based nanoparticles [116]
Medulloblastoma miR-17 ~ 92 cluster family – Sonic Hedgehog signaling 8-mer seed-targeting locked nucleic acid (LNA)-modified anti-miR oligonucleotides (nude mice) [117]
Pancreatic cancer miR-21 – Oncogene Lentiviruses [118]
  1. * The miRNA target can be modulated by anti-miRNA oligonucleotides or miRNA-expressing constructs (delivered by viral or non-viral vectors).