Skip to main content

Table 6 Novel approaches to circumvent chemoresistance by modulating unique miRNAs

From: MicroRNA: a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy

Cancer type miRNA targeted for inhibition Type of resistance circumvented Delivery system for modulation of miRNAs Reference
B-cell lymphoma miR-21 – oncomiR addiction -- Antisense strategy [119]
Cholangiocarcinomas miR-21 & miR-200b Gecitabine resistance mediated by PTEN-dependent activation of PI3K signaling Transfection with miRNA-specific antisense oligonucleotides [120]
Glioblastoma Multiforme (GBM) miR-9 – indirectly promoting expression of the MDR transporter P-gp P-gp-mediated resistance to temozolomide - Mesenchymal stem cell-derived exosomes [112]
- To deliver anti-miR-9 to temozolomide-resistant GBM to reduce P-gp expression for resistance reversal
GBM miR-21 - Temozolomide Transfection with anit-miR-21 oligonucleotide [121]
- Enhance apoptosis
Lung cancer miR-92b Cisplatin resistance mediated by downregulation of the tumor suppressor gene PTEN Transfection with anti-miR-92b oligonucleotide [122]