Table 6 Novel approaches to circumvent chemoresistance by modulating unique miRNAs
Cancer type | miRNA targeted for inhibition | Type of resistance circumvented | Delivery system for modulation of miRNAs | Reference |
|---|---|---|---|---|
B-cell lymphoma | miR-21 – oncomiR addiction | -- | Antisense strategy | [119] |
Cholangiocarcinomas | miR-21 & miR-200b | Gecitabine resistance mediated by PTEN-dependent activation of PI3K signaling | Transfection with miRNA-specific antisense oligonucleotides | [120] |
Glioblastoma Multiforme (GBM) | miR-9 – indirectly promoting expression of the MDR transporter P-gp | P-gp-mediated resistance to temozolomide | - Mesenchymal stem cell-derived exosomes | [112] |
- To deliver anti-miR-9 to temozolomide-resistant GBM to reduce P-gp expression for resistance reversal | ||||
GBM | miR-21 | - Temozolomide | Transfection with anit-miR-21 oligonucleotide | [121] |
- Enhance apoptosis | ||||
Lung cancer | miR-92b | Cisplatin resistance mediated by downregulation of the tumor suppressor gene PTEN | Transfection with anti-miR-92b oligonucleotide | [122] |