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Figure 1 | Journal of Biomedical Science

Figure 1

From: Malondialdehyde mediates oxidized LDL-induced coronary toxicity through the Akt-FGF2 pathway via DNA methylation

Figure 1

Role of the MDA epitope on the oxLDL-induced reduction of DNA synthesis, as determined by measuring 3H-thymidine incorporation. Cultured human coronary artery endothelial cells were incubated for 24 hours with or without oxLDL (100 μg/ml) in the presence or absence of anti-MDA (0.01, 0.05, or 0.15 μg/ml), anti-apoB100 (0.15 μg/ml), or FGF2 (50 ng/ml). Values shown are the mean ± SEM (n = 3). *P < 0.05, **P < 0.01 vs the oxLDL-untreated, PBS-treated control (first black column). P < 0.05 between the indicated pair. MDA, malondialdehyde; oxLDL, oxidized low-density lipoprotein.

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