The human FGF2 gene promoter. (A) Schematic representation of the CpG island promoter of human FGF2. The numbers are the nucleotide positions relative to the +1 transcription start site. Each CpG dinucleotide is shown by a vertical line. (B) Part of the genomic DNA sequence of FGF2 is shown, featuring the FGF2 promoter, GC boxes (outlined), and CpG dinucleotides (shaded). The CpG island start site (downward arrow in B), the exon-intron boundary (triangle in B), and the translation start codon (CTG in B) are indicated.