Effect of BBD on cell viability and cytotoxicity of PC12 and BV-2 cells under hypoxia. The cells were treated with hypoxia alone or in the presence of various concentrations (1, 10, 20 μM) of BBD for 30 min. Cell viability of PC12 (A) and BV-2 cells (C) was increased and the LDH release, reduced (B, D) from hypoxia dose-dependently by BBD. Data are expressed as mean ± SEM of three independent experiments in triplicate. *: P < 0.05 as compared to the hypoxia control.