Skip to main content
Figure 5 | Journal of Biomedical Science

Figure 5

From: Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on ischemic and hypoxic neuronal injury

Figure 5

BBD inhibited hypoxia-induced phospho-JNK MAP kinase, AKT-1, COX-2 and Caspase-3 under hypoxia. The effect of BBD (1, 10, 20 μM) on hypoxia-activated cell signaling pathways was determined by Western blotting under hypoxia stress in BV-2 cells for 10 min (A) and for 30 min (B). Similarly, BBD effectively reduced the activation of JNK MAP kinase and COX-2 (C, D) in PC12 cells. C: normal control. Data are expressed as mean ± SEM of three independent experiments. *: P<0.05 as compared to hypoxia control.

Back to article page