Histological findings. Sham prostate treated with vehicle showing regular acini with cubodail epithelium with round nuclei showing a regular alignment (A). BPH prostate treated with vehicle showed irregular acinar shape with villous projection into the lumen and foci of piling-up hyperplastic nodule with loss of epithelial polarity are evident. The epithelium is cylindric/cuboidal and round/ovoid nuclei are irregularly aligned. Presence of hard stroma and an intact basal layer surrounding the acini (B). Similarly, BPH prostate treated with SeR and Se displayed cilindric/cuboidal epithelial cells but villous projections are just slightly present or absent, respectively. Moderate stroma and intact basal layer around the acini (C-D). Treatment with Ly proved cuboidal epithelial cells, absence of villous projection and the presence of moderate stroma with intact basal layer around the acini (E). Differently, BPH prostate treated with the combination SeR-Se-Ly resembled the histological features of a normal acinar structure (F) (Original magnification ×100 and ×400 in the box).