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Figure 3 | Journal of Biomedical Science

Figure 3

From: Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells

Figure 3

The HPSE inhibitor OGT2115 did not affect osteogenic differentiation of mouse BM-MSCs. (A) The expression levels of Hpse1 increased during osteogenic differentiation. (B) Osteogenic potential was characterized by ARS staining after 21 days induction at the fourth passage of BM-MSCs with or without OGT2115. Quantifications of ARS staining of OGT2115 and control groups showed no difference (nā€‰=ā€‰3). (C) Quantitative real-time PCR analysis on the mRNA expression levels of Mmp2, Mmp9 and Mmp14 with or without the treatment of OGT2115 detected a significantly increased Mmp9 expression when HPSE1 is enzymatically inhibited. Error bars represent standard deviation.

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