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Figure 4 | Journal of Biomedical Science

Figure 4

From: Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells

Figure 4

HPSE1 promoted self-renewal of mouse BM-MSCs. (A) Cell numbers were evaluated by MTT assay 0, 2, 4 and 6 days after the treatment of various concentrations of OGT2115. The results revealed that OGT2115 inhibited cell proliferation of BM-MSCs at fourth passage in a dose-dependent manner (n = 3). (B) The CFUs were significantly decreased by the treatment of OGT2115 (OGT) compared to the DMSO control, while the combined treatment of both mouse recombinant HPSE1 and OGT2115 (O + H) reversed the statistical significance (n = 3). (C-E) The inhibitory effect on BM-MSCs proliferation of OGT2115 was consistently reproduced at P2 (C), P4 (D) and P6 (E). *P < 0.05; **P < 0.01; ***P < 0.001.

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