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Figure 4 | Journal of Biomedical Science

Figure 4

From: Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis

Figure 4

Tryptase regulates expression of p53 in U87 cells. STAT3-sufficient or deficient U87 cells were cultured and radiated in the presence of tryptase or active PAR2 peptides for 48 h. The cells were analyzed for the expression of p53 by qRT-PCR and Western blotting respectively. A, the bars indicate the mRNA levels of p53 (mean ± SD; *, p < 0.01, compared with naive group). B, the immune blots indicate the protein levels of p53. C, the STAT3 gene knockdown results. The data represent 3 separate experiments. STAT3d: STAT3 deficient U87 cells. PAR2d: PAR2-deficinet U87 cells. cshRNA: Radiated U87 cells were treated with control shRNA. The data represent 3 separate experiments.

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