A schema of functions of DGKs in brain. DGKβ regulates spine formation and branching, contributing to higher brain functions including memory and emotion. DGKζ and ι are involved in spine maintenance and neurotransmitter modulation, respectively. DGKϵ and δ are reported to be related to mood disorder. DGKη seems to be correlated to seizure. The control of membrane DG and PA is a key step, and protein-protein interaction like DGKζ and PSD95 is critical for the functions of DGKs.