Figure 7
Model of the effect of shear stress on S-nitrosation of redox-sensitive Cys-containing proteins in ECs. Shear stress activates endothelial nitric oxide synthase (eNOS), leading to an increased level of NO and increased S-nitrosation (S-NO) of proteins via NO carrier proteins or peptides. Shear stress-induced protein’s S-nitrosation may prevent the irreversible oxidative modification of proteins (S-OH and S-O2/O3H) that otherwise would occur during severe inflammation [73].