Silencing PTER expression diminished albuminuria-induced renal tubular cell activation. The PTER siRNA (siRNA), negative control RNA (scRNA) and transfection reagent alone (TR) transfected HK-2 cells were treated with 1 mM HSA for 24 h for real-time PCR analysis. The mRNA expression levels of PTER (A), MCP-1 (B), RANTES (C) and TGF-β1 (D) were normalized to GAPDH, and the results are presented as mean ± SD. Total cell protein was extracted at the indicated time points and subjected to analysis of the PTER protein expression levels (E). The relative expression levels were normalized to β-actin and the results were presented as mean ± SD (F). a, p < 0.05 in comparison with the control group; b, p < 0.05 in comparison with the HSA group.