Effects of antisense oligodeoxynucleotides (AODN) or random AODN (10 μg/3 μl, icv) pretreatment against D
R mRNA for 2 days on MBH D
R mRNA ratios (upper; arbitrary unit), ME DOPAC/DA (middle) and serum PRL (lower) levels both in the morning and afternoon in OVX+E
rats. Data are expressed as mean ± SEM (n = 5–7 rats for DOPAC/DA ratio and PRL level; n = 12–14 rats for MBH D2R mRNA in each treatment group). *, p < 0.05; ** p < 0.01, compared with respective control groups in the morning; #, p < 0.05; ##, p < 0.01 compared with respective control groups in the afternoon.