Skip to main content
Figure 2 | Journal of Biomedical Science

Figure 2

From: Attenuated neuroprotective effect of riboflavin under UV-B irradiation via miR-203/c-Jun signaling pathway in vivo and in vitro

Figure 2

UV-B irradiation induces photodegradation and attenuation of the neuroprotective effects of RF in human neuroblostoma SH-SY5Y cell lines. (A) LC-MS/MS spectrum of parent RF (376 Da) and (B) two major photoproducts P1 (360.4 Da) and P2 (343.2 Da) after UV-B (0.6 mW/cm 2 for 1 h) irradiation. (C) RF treatment significantly inhibits OGD induced LDH release compared to that of UV-B-RF treatment (D) RF treatment significantly rescues cell viability compared to that of UV-B-RF treatment in Human neuroblostoma SHSY5Y cell line. The average of three independent experiments performed in triplicate is shown. Statistical significance was analyzed by ANOVA. Values are the mean ± SEM *p < 0.05 and **p < 0.01 vs. RF treated and control group.

Back to article page