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Figure 8 | Journal of Biomedical Science

Figure 8

From: Synthesis and activity of three new trinuclear platinums with cis-geometry for terminal metal centres

Figure 8

Electrophoretograms applying to the incubated mixtures of pBR322 plasmid DNA and varying concentrations of QH4, QH7, QH8 and cisplatin followed by digestion with BamH1. Lane B1 applied to the untreated pBR322 plasmid DNA and undigested with BamH1, lane B2 applied to untreated but digestion with BamH1. Lanes 1 to 8: apply to pBR322 plasmid DNA interacted with increasing concentrations of the compounds followed by BamH1 digestion. The concentrations for QH4, QH8 and cisplatin were: lane 1: 0.55 μM, lane 2: 1.09 μM, lane 3: 2.19 μM, lane 4: 4.38 μM, lane 5: 8.75 μM, lane 6: 17.50 μM, lane 7: 35.00 μM, and lane 8: 70.00 μM. The concentrations for QH7 is as follows lane 1: 0.12, lane 2 : 0.23, lane 3: 0.47, lane 4: 0.94, lane 5:1.88, lane 6: 3.75, lane 7: 7.50 and lane 8: 15.00.

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