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Table 1 IC 50 (μM) values and RFs for compounds against A2780, A2780 cisR , A2780 ZD0473R cell lines

From: Synthesis and activity of three new trinuclear platinums with cis-geometry for terminal metal centres

Compounds IC 50 [ a ]
A2780 A2780cisR RF[b] A2780ZD0473R RF[c]
Cisplatin 1.09 ± 0.06 8.08 ± 1.03 7.45 4.28 ± 0.33 3.95
QH4 0.62 ± 0.11 9.24 ± 0.53 14.91 5.22 ± 0.21 8.42
QH7 8.87 ± 0.01 6.45 ± 0.47 0.73 4.61 ± 0.46 0.52
QH8 0.55 ± 0.02 4.48 ± 0.49 8.15 4.41 ± 0.22 8.02
  1. [a]IC50 values are drug concentrations required for 50% cell death and are the means ± SD from quadruplicate determinations of at least three independent experiments. [b]RF standing for resistant factor is the ratio of IC50 value in resistant cell line to that in the parent cell line. [c]RF resistant factor applying to the cell lines A2780 and A2780ZD0473R.