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Table 1 IC 50 (μM) values and RFs for compounds against A2780, A2780 cisR , A2780 ZD0473R cell lines

From: Synthesis and activity of three new trinuclear platinums with cis-geometry for terminal metal centres

Compounds

IC 50 [ a ]

A2780

A2780cisR

RF[b]

A2780ZD0473R

RF[c]

Cisplatin

1.09 ± 0.06

8.08 ± 1.03

7.45

4.28 ± 0.33

3.95

QH4

0.62 ± 0.11

9.24 ± 0.53

14.91

5.22 ± 0.21

8.42

QH7

8.87 ± 0.01

6.45 ± 0.47

0.73

4.61 ± 0.46

0.52

QH8

0.55 ± 0.02

4.48 ± 0.49

8.15

4.41 ± 0.22

8.02

  1. [a]IC50 values are drug concentrations required for 50% cell death and are the means ± SD from quadruplicate determinations of at least three independent experiments. [b]RF standing for resistant factor is the ratio of IC50 value in resistant cell line to that in the parent cell line. [c]RF resistant factor applying to the cell lines A2780 and A2780ZD0473R.
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Journal of Biomedical Science

ISSN: 1423-0127