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Table 2 Polymorphisms at miRNA and miRNA processing genes and risk of leukoplakia (Only SNPs with significant p-values are shown)

From: Association between risk of oral precancer and genetic variations in microRNA and related processing genes

Gene (SNP)c Genotype and Alleles Control (%)/leukoplakia (%) O.R (95% C.I)a p- value
Gemin3(rs197412) TT + CT 389(87)/ 273(92) Ref 0.03
  CC 58(13)/ 25(8) 0.5(0.3–0.9)
  T 580(62)/ 417(70) Ref 0.04
  C 314(38)/ 179(30) 0.7(0.6–0.9)
mir34b(rs2187473) CC 153(35)/ 116(41) Ref 0.05
  CT + TT 286(65)/ 166(59) 0.7(0.5–0.9)
  C 527(60)/ 357(63) Ref 0.29
  T 351(40)/ 207(37) 0.8 (0.7–1.1)
Within Tobacco Stratified Individuals
(bTobacco Smokers : Controls- 267/Leukoplakia-255)
Gemin3(rs197412) TT + CT 222(86)/230(92) Ref 0.05
  CC 35(14)/21(8) 0.58(0.3–1)
mir34b(rs2187473) CC 80(32)/98(41) Ref 0.04
  CT + TT 169(68)/140(59) 0.68(0.5–0.9)
(bTobacco Chewers : Controls-277/Leukoplakia-129)
mir29a(rs24168) GG + AG 228(84)/78(74) Ref 0.05
  AA 44(16)/27(26) 1.8(1–3)
  1. aadjusted for age, sex and tobacco habits.
  2. bSmokers/chewers include exclusive smokers/chewers along with mixed habitués.
  3. cGemin3- Dominant model; mir34b and mir29a-Recessive model (with respect to risk allele).
  4. Few individuals could not be genotyped at certain loci.