Figure 3
From: Downregulation of Sirt1 as aging change in advanced heart failure
Apoptosis and oxidative stress are aggravated in advanced heart failure. Atrial myocardial sections from the recipient and donor patients were subjected to (A) TUNEL, troponin C and DAPI staining, the number of TUNEL-positive myocytes was expressed as a percentage of total nuclei detected by DAPI staining. and (B) 8-OHdG immunostaining. Representative images of the staining are shown. (C) The ventricular myocardial sections of hearts from old (15 months) and young (3 months) mice were subjected to immunostaining with 8-OHdG, and representative images of the staining are shown.