Figure 1

Caveolin-3 topological domains and localization of the V82I variation identified in LQTS patient. (a) Schematic topological organization of the caveolin-3 protein. Numbers above the line indicate amino acid residues in caveolin-3 protein sequence that define four domains (23): N-terminal (aa 1–53), scaffolding (aa 54–73), transmembrane (aa 74–106) and C-terminal (aa 107–151). V82I mutation affects a residue within the transmembrane domain. (b) Sequence alignment of caveolin-3 protein of the indicated vertebrates is shown. V82I mutation modifies a conserved amino acids in caveolin-3.