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Figure 1 | Journal of Biomedical Science

Figure 1

From: A new pharmacological role for donepezil: attenuation of morphine-induced tolerance and apoptosis in rat central nervous system

Figure 1

Analgesic effect of daily administration of morphine (10 mg/kg, ip) in combination with morphine + 0 mg/kg donepezil (control group). Developed tolerance to the analgesic effect of morphine was complete on the 14th day when there were no significant differences in percentage of maximal possible effect (%MPE) between the control groups and the saline group. Each bar represents the mean of%MPE ± sem for eight rats. M = Morphine.

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Journal of Biomedical Science

ISSN: 1423-0127